Event Details

The nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in multiple solid tumor-derived cell lines and research in my laboratory demonstrates that NR4A1 is pro-oncogenic and regulates genes/pathways associated with cell growth, survival and migration/invasion. Our research has also identified bis-indole derived ligands which act as receptor antagonists and block NR4A1-regulated effects. This presentation will highlight studies on the mechanism of action of our NR4A1 antagonists and recent discoveries on the chemotherapeutic efficacy of these compounds. For further information check PubMed citations.